PL02.4.A International validation study of an EORTC instrument measuring instrumental activities of daily living (IADL) in patients with brain tumours: EORTC IADL-BN32
نویسندگان
چکیده
Abstract Background Brain tumour patients often have neurocognitive deficits which can result in problems with activities daily living that are cognitively complex. Currently, no valid and reliable brain tumour-specific instrument to measure these instrumental of (IADL) is available, but such an being developed. This study aimed validate the EORTC IADL-BN32 questionnaire, comprising five multi-item two single item scales, a large set international patients. Material Methods was conducted 10 countries worldwide. Primary metastatic their proxies were requested complete subjective cognitive questionnaire (MOS COG-R) at multiple time points. Several psychometric properties evaluated baseline data, including structural validity (bi-factor confirmatory factor analysis [CFA]), reliability (internal consistency), construct (known groups comparisons) patient-proxy congruency (intra-class correlation coefficients [ICC], Spearman's correlation). Results At baseline, 326 ( 30% low-grade glioma, 37% high-grade glioma (HGG) 33% metastases) 311 completed IADL-BN32. The bi-factor CFA found satisfactory model fit (CFI=0.92 TLI=0.90), other parameters indicated good (RMSEA=0.08 SRMR=0.05), thereby validating preliminary scale structure, also IADL sum score. scales showed (0.9>α≥0.8) excellent (α≥0.9) internal consistency (range α=0.86-0.97). Known comparisons analyses regarding patient’s status (indications vs. impairment), complaints COG-R ≤30 >30), basic ADL (Barthel Index <100 100) performance (KPS <70 ≥70) significant differences on all outcome measures line priori defined hypotheses. On group level, patient proxy ratings had moderate strong correlations, however, tended report more scales. ICCs between ICC: 0.63-0.81). Conclusion support current structure Additional longitudinal data needed, as test-retest responsiveness, further EORTC-IADL BN32 questionnaire.
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ژورنال
عنوان ژورنال: Neuro-oncology
سال: 2022
ISSN: ['1523-5866', '1522-8517']
DOI: https://doi.org/10.1093/neuonc/noac174.007